THE ELECTROCHEMICAL BEHAVIOR OF
SOME BETA-BLOCKERS ON SCREEN PRINTED
ELECTRODES MODIFIED WITH CALIXARENE.
GABRIELA DUŢU1, CECILIA CRISTEA1, BODOKI EDE1,
VERONICA HÂRCEAGĂ1, ALINA SAPONAR2, ELISABETHJEANNE
POPOVICI2, ROBERT SĂNDULESCU1
1 Iuliu Haţieganu University of Medicine and Pharmacy, Faculty of
Pharmacy,Analytical Chemistry, Pasteur str., no. 4, 300249 Cluj-
Napoca, Romania,
2 Babeş-Bolyai University Cluj-Napoca, Faculty of Chemistry and
Chemical Engineering, Physical Chemistry, Arany Janos str, no. 11,
300410 Cluj-Napoca, Romania
*corresponding author: rsandulescu@umfcluj.ro
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Abstract:

The aim of this work was to study the electrochemical behavior of metoprolol succinate, atenolol and propranolol hydrochloride, respectively.
The first part of the cyclic voltamperommetric studies was performed using classical platinum, gold and vitreous carbon electrodes, aiming the electrochemical behavior of beta-blockers at different pH values (5.22-8.59).
The second part of the studies was performed using gold electrodes modified with calixarenes. In the case of using modified electrodes with calixarenes, compared to the unmodified ones, it was observed that the redox process has decrease, due to an interaction between the calixarenes and beta-blocker. This interaction is sustained also by the performed computational chemistry calculations.

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