MATHEMATICAL MODELING OF
4-[(2-ISOPROPOXYETHOXY)METHYL]PHENOL
SYNTHESIS.
GABRIELA PESTE1, NELA BIBIRE2, RODICA DIACONESCU3 ,
CORNELIU ONISCU 3
1Center for Drug Evaluation, Antibiotice S.A., Valea Lupului, 1 Street,
707410, Iasi, Romania
2“Gr.T. Popa“ University of Medicine and Pharmacy of Iasi, Faculty of
Pharmacy, Department of Analytical Chemistry, 16 University Street,
700115, Iasi, Romania
3Technical University “Gheorghe Asachi” of Iasi, Faculty of Chemical
Engineering, 73 Mangeron Dimitrie Street, 700050, Iasi, Romania
􀀀corresponding author: gabrielapeste@yahoo.com
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Abstract:

The most difficult step in the industrial manufacturing of bisoprolol fumarate, an important beta-blocker agent, is the synthesis of 4-[(2-isopropoxyethoxy)methyl]phenol, which is influenced by three main parameters : 2-isopropoxy ethanol/4-hydroxybenzyl alcohol molar ratio, reaction time and temperature. In order to establish the optimum reaction conditions, an experimental factorial design was accomplished, in which the real values of the parameters and their limits of variation were randomly chosen. The mathematical modeling of 4-[(2-isopropoxyethoxy) methyl]phenol obtaining process enabled to settle the optimum values of the parameters for a maximum yield in 4-[(2- isopropoxyethoxy) methyl]phenol synthesis.

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