CHEMICAL COMPOSITION OF THE TUNISIAN
NIGELLA SATIVA. NOTE I. PROFILE ON
ESSENTIAL OIL.
CLAUDIA-CRINA TOMA1*, GEORGETA MARIA SIMU2, DANIELA
HANGANU3, NELI OLAH4, FLORINA MARIA GEORGIANA
VATA5, CYRINE HAMMAMI6, MOHAMED HAMMAMI6
1 Department of Pharmacognosy, Faculty of Pharmacy, "Vasile Goldis"
Western University of Arad, 1 Feleacului Street, 300041, Romania,
2 Institute of Chemistry Timisoara of the Romanian Academy, 24 Mihai
Viteazul Blvd., 300223 Timişoara, Romania
3Department of Pharmacognosy, Faculty of Pharmacy, “Iuliu
Haţieganu” University of Medicine and Pharmacy, Cluj – Napoca, 15
I.Creangă Street, Romania
4 Department of Pharmaceutical Industry, Faculty of Pharmacy, "Vasile
Goldis" Western University of Arad, 1 Feleacului Street, 300041,
Romania
5 Department of Toxicology, Faculty of Pharmacy, "Vasile Goldis"
Western University of Arad, 1 Feleacului Street, 300041, Romania
6 Faculty of Medicine of Monastir, Salem BCHIR Skanes Street, 5000
Monastir, Tunisia
*corresponding author: claudiatoma2004@yahoo.com
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Abstract:

Nigella sativa L., Ranunculaceae Family, commonly named blackseed, is a spontaneous plant. Nigellae sativae semen was used for a long time in the Arabian and Romanian ethnopharmacological field for its tonic effect. The scientific basis for using this plant was confirmed by phytochemical studies. These studies represent the scientifical confirmation of the empirical use of this vegetal product. The main compounds from the lipophylic fraction are responsible for the pharmacological activity of the Nigellae sativae semen. The qualitative and quantitative analysis of the essential oil were performed using a gas-chromatography-mass spectrometry (GC-MS) method. The analysis of the Nigella sativa essential oils extracts allowed the identification of 30 compounds in considerable percentages, among them: alpha- pinene (13.75 %), limonene (2.55 %), p-cymene (43.58 %), carvacrol (2.53 %) and tymoquinone (1.65 %). The results show that the essential oils composition depends in a great extent on the used extraction technique, and this offers the possibility to choose the methods which could favour the isolation of certain compounds.




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