PHARMACOKINETIC INTERACTION STUDY
BETWEEN IVABRADINE WITH FLUOXETINE
OR METRONIDAZOLE IN HEALTHY
VOLUNTEERS.
LAURIAN VLASE1*, ADINA POPA2, MARIA NEAG2, DANA
MUNTEAN1, SORIN E. LEUCUŢA1
1Faculty of Pharmacy, Department of Pharmaceutical Technology and
Biopharmaceutics,
2Faculty of Pharmacy, Department of Clinical Pharmacy, “Iuliu
Haţieganu” University of Medicine and Pharmacy, Cluj-Napoca, 13 Emil
Isac, 400023, Romania
*corresponding author: vlaselaur@yahoo.com
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Abstract:

The pharmacokinetic interaction between ivabradine with fluoxetine and metronidazole in healthy volunteers was evaluated. In two separate experiments, a single dose of either 5 or 10 mg ivabradine was administered alone or in combination with fluoxetine or metronidazole to 18 healthy male volunteers in a two treatment study design, separated by a period in which the fluoxetine or metronidazole alone were administrated daily. The pharmacokinetic parameters of ivabradine administered alone or in combination with fluoxetine or metronidazole were calculated using the non-compartmental analysis.
Non-statistically significant differences have been observed for the main pharmacokinetic parameters of ivabradine when administered alone or with fluoxetine or metronidazole, demonstrating the lack of pharmacokinetic interaction between these drugs.

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