THIN-LAYER CHROMATOGRAPHY ANALYSIS
FOR CYCLODEXTRINS INCLUSION
COMPLEXES OF FOSINOPRIL AND
ZOFENOPRIL.
LAURA SBÂRCEA1*, LUCREŢIA UDRESCU2, LIANA DRĂGAN1,
CRISTINA TRANDAFIRESCU1, ZOLTAN SZABADAI2, MARIUS
BOJIŢĂ3
1“Victor Babeş” University of Medicine and Pharmacy Timişoara,
Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Eftimie
Murgu Str. No. 2, Timişoara, România
2“Victor Babeş” University of Medicine and Pharmacy Timişoara,
Faculty of Pharmacy Department of Drug Analysis
3“Iuliu Haţieganu” University of Medicine and Pharmacy, Faculty of
Pharmacy Cluj-Napoca, Department of Drug Analysis, Louis Pasteur Str.
No.6 ,Cluj-Napoca, România
*corresponding author: laura_sbarcea@yahoo.com
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Abstract:

The aim of this paper is to emphasize the inclusion complex character between fosinopril, zofenopril and natural and semisynthetic cyclodextrins (β-cyclodextrin, hydroxypropyl-β-cyclodextrin and randomly methylated-β-cyclodextrin), using thin-layer chromatography.
Fosinopril and zofenopril are the most hydrophobic substances among the angiotensin-converting enzyme inhibitors; the cyclodextrins are used to improve the physico-chemical properties of pharmaceutical substances in order to enhance some biopharmaceutical properties of the drugs.
Binary systems angiotensin-converting enzyme inhibitor – cyclodextrin were
prepared using the kneading method, in 1:1 molar ratio. Thin-layer chromatography reveals that the inclusion complexes show lower hRf values compared to those of the angiotensinconverting enzyme inhibitors, as an index of molecular interaction between the components, due to the formation of inclusion complexes.

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