ANTIMICROBIAL AND SYNERGISTIC ACTIVITY OF SOME WHOLE
AND SELECTIVE EPILOBIUM HIRSUTUM L. (GREAT WILLOWHERB)
EXTRACTS TESTED ON STANDARD AND WILD STAPHYLOCOCCUS
AUREUS STRAINS

LUCIA PIRVU1, VALENTIN NICORESCU2*, CRISTINA HLEVCA1, DENISA IOANA UDEANU3, ISABELA NICORESCU4
1National Institute for Chemical Pharmaceutical R&D (INCDCF), Vitan 112, 031299, Bucharest, Romania
2University of Agronomic Sciences and Veterinary Medicine of Bucharest, Faculty of Veterinary Medicine, Splaiul
Independentei 105, 050097, Bucharest, Romania
3University of Medicine and Pharmacy “Carol Davila”, Bucharest, Faculty of Pharmacy, Department of Clinical Laboratory
and Food Safety, Traian Vuia 6, 020956, Bucharest, Romania
4Institute of Hygiene and Veterinary Public Health, Campul Mosilor 5, 021201, Bucharest, Romania
*corresponding author: valinicorescu@yahoo.com
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Abstract:
This work aimed to establish Epilobium hirsutum L. (Onagraceae family) aerial part whole and selective extracts
antimicrobial activity and possible synergism with some antibiotics (Gentamicin, Tetracycline, Ampicillin, Nalidixic acid and
Ciprofloxacin) tested on standard and wild methicillin–resistant Staphylococcus aureus (MRSA) strains; the vegetal extracts
had identical total phenols content, 5 mg gallic acid (GAE) equivalents 1 mL extract respectively. Thus, there were evidenced
stimulatory effects between great willowherb extracts and Ampicillin; statistically significant differences were also obtained
for the combination with Gentamicin and Ciprofloxacin, in these cases being recorded smaller inhibition zones compared to
those of the antibiotics used alone (inhibitory effects).






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