FORMULATION AND EVALUATION OF IN VITRO RELEASE
KINETICS OF NA3CADTPA DECORPORATION AGENT EMBEDDED
IN MICROEMULSION-BASED GEL FORMULATION FOR TOPICAL
DELIVERY

VICTOR COJOCARU1, AURELIAN EMIL RANETTI2, LAVINIA GEORGETA HINESCU3, MIHAELA IONESCU3, CRISTIANA COSMESCU3, ANGELA GABRIELA POȘTOARCĂ3, LUDMILA OTILIA CINTEZĂ4*
1“Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, 6 Traian Vuia, 020956, Bucharest, Romania
2“Carol Davila” Military Hospital, 88 Mircea Vulcănescu, 010825, Bucharest, Romania
3Army Center for Medical Research, 24-28 Gr. Cobălcescu, 010195, Bucharest, Romania
4University of Bucharest, Faculty of Chemistry, 4-12 Regina Elisabeta, 030018, Bucharest, Romania
*corresponding author: ocinteza@yahoo.com
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Abstract:
The purpose of this study was to evaluate the in vitro release kinetics of Na3CaDTPA, a well-known and widely-used
decorporation agent, from a topical microemulsion-gel formulation in comparison with a conventional gel. For the
preparation of hydrogels, Carbopol 934 polymer was used. Release studies were conducted using both hydrophobic
(polycarbonate) and hydrophilic (mixed cellulose esters) membranes. The release kinetics were evaluated using Franz
diffusion cells. The receptor compartment was filled with phosphate buffer pH 7.4 and magnetically stirred at 600 rpm during
the experiments. The temperature of the entire setup was maintained at 32 ± 0.5°C. The microemulsion-gel showed a higher
diffusion coefficient and a smaller lag time compared to the conventional gel. The release profiles were evaluated using
different kinetic models: zero-order, first-order, Higuchi and Korsmeyer-Peppas. Mathematical modelling of the drug release
data suggested a quasi-Fickian diffusion mechanism for both conventional and microemulsion-based hydrogels.






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