SYNTHESIS AND EVALUATION OF ANTIMICROBIAL
ACTIVITY OF NEW 2-MERCAPTO-3-SUBSTITUTED-1,4-
NAPHTHOQUINONES (I)

GABRIELA RĂU1#, FLAVIA MARIA CREŢU1#, ANA MARINA ANDREI1, CĂTĂLINA GABRIELA PISOSCHI1*, GEORGE DAN MOGOŞANU1, ADELA BOROGHINĂ2, ILEANA MONICA BANIŢĂ1,3, CAMELIA ELENA STĂNCIULESCU1
1University of Medicine and Pharmacy, 2-4 Petru Rareş, 200349, Craiova, Dolj, Romania
2Emergency Clinical County Hospital, 1 Tabaci, 200642, Craiova, Dolj, Romania
3Clinical Hospital of Neuropsychiatry, 99 Calea București, 200473, Craiova, Dolj, Romania
*corresponding author: c_pisoschi@yahoo.com
#These authors contributed equally to this work.
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Abstract:
Compounds bearing the 1,4-naphthoquinone ring and sulphur containing derivatives had been the subject of much interest
due to their antimicrobial, antiviral, anti-inflammatory and anti-tumoural activities. Design of new derivatives of
naphthoquinones, in order to improve their pharmaceutical properties, is still a research area of utmost importance. In the
present study, we describe the synthesis, physico-chemical properties and evaluation of antimicrobial activity of new 2-
mercapto-3-substituted-1,4-naphthoquinones. For the synthesis we used different 2-chloro-3-substituted-1,4-naphthoquinones
and thiourea. The new naphthoquinone derivatives were characterized by elemental analysis, UV-VIS and IR spectrometry,
mass spectrometry and 1H–NMR. All this methods confirmed the structure of the compounds. The antimicrobial activity was
tested on several Gram-positive and Gram-negative bacteria using disk diffusion technique. In general, the compounds were
active against tested Gram-positive bacteria. This encourages further studies for application of these compounds as antibiotic
therapy.






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