PHYTOBIOLOGICAL ASSESSMENT OF SOME NEW COMPOUNDS
WITH DIBENZO[a,d][7]ANNULENE MOIETIES

LAURA-ILEANA SOCEA1, BOGDAN SOCEA2, NICOLETA POESINA DIMCEVICI3, MIHAELA DINU4*, CERASELA ELENA GÎRD5
“Carol Davila” University of Medicine and Pharmacy
1Organic Chemistry Department, Faculty of Pharmacy, Traian Vuia 6, 020956, Bucharest, Romania
2Faculty of Medicine, St. Pantelimon Emergency Hospital, Pantelimon 340-342, 021623, Bucharest, Romania
3Applied Mathematics and Biostatistics Department, Faculty of Pharmacy, Traian Vuia 6, 020956, Bucharest, Romania
4Pharmaceutical Botany and Cell Biology Department, Faculty of Pharmacy, Traian Vuia 6, 020956, Bucharest, Romania
5Pharmacognosy Phytochemistry Phytotherapy Department, Faculty of Pharmacy, Traian Vuia 6, 020956, Bucharest,
Romania
*corresponding author: mihaela_dinu_pini@yahoo.com
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Abstract:
5H-Dibenzo[a,d][7]annulene ring compounds get an increasing attention because of their multiple applications, especially in
the medical field. For this reason, we have considered useful to apply phytobiological tests of some compounds having 5Hdibenzo[
a,d][7]annulene ring, using the Constantinescu method, Triticum test. Synthesis of these compounds was described
in our previous papers. The influence of the compounds tested on wheat embryonic root elongation depends both on chemical
structure and on concentration, most compounds presenting mitoinhibitory activity, without presenting a cytotoxic effect.
Hydrazinecarbothioamide substituted in position 4 with 4-fluorophenil radical has a cytotoxic effect for the most
concentrated tested solution.






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