CONTENT


FARMACIA Nr.6, 2007:

  1. PHARMACEUTICAL APPLICATIONS OF IONIC ASSOCIATIONS. NOTE I.
    MARINELA FLOREA, CRINA-MARIA MONCIU, CORINA-CRISTINA ARAMĂ
    Abstract


  2. PATIENT EDUCATION - A NEED FOR THE RATIONAL USE OF ANTIBIOTICS.
    CORINA MACAVEI, CODRUTA MAIER, M. BOJITĂ
    Abstract


  3. NEW AMIDES OF 2-PHENOXYMETHYL-BENZOIC ACIDS AS POTENTIAL ANTIMICROBIAL AGENTS.
    DIANA CAMELIA NUTĂ, CARMEN LIMBAN, CAMELIA ELENA STECOZA, L. MORUSCIAG, CORINA ILIE, M.T. CĂPROIU, G.M. NITULESCU, CARMELLINA BĂDICEANU
    Abstract


  4. DETERMINATION OF PHYSICO-CHEMICAL AND FLOW PROPERTY OF COMMONLY USED DIRECT COMPRESSION BINDER -FILLER POWDERS.
    ESAM. A. RAMADAN
    Abstract


  5. SYNTHESIS AND ANTICANCER ACTIVITY IN VITRO OF SOME 2-THIOXO-4-THIAZOLIDONE DERIVATIVES.
    OLEXANDRA ROMAN, ROMAN LESYK
    Abstract


  6. BIOAVAILABILITY STUDY ON ACETAMINOPHEN TABLETS FROM THE LIBYAN MARKET. IN VITRO/IN VIVO CORRELATION .
    ESAM. A. RAMADAN
    Abstract


  7. EXPERIMENTAL PHARMACOLOGICAL RESEARCHES REGARDING ACUTE TOXICITY AND THE EFFECT ON BASELINE GLYCAEMIA OF SOME NEWLY SYNTHETIZED BETA3 ADRENERGIC RECEPTORS AGONISTS .
    SIMONA NEGRES, CORNEL CHIRITĂ, CRISTINA ZBÂRCEA, AURELIA NICOLETA CRISTEA, ELENA MOROSAN, DENISA MIHELE, GABRIELA PUTINA
    Abstract


  8. EVALUATION OF SOME RHEOLOGICAL PARAMETERS FOR SODIUM CARBOXYMETHYLCELLULOSE TOPICAL HYDROGELS WITH INDOMETHACIN .
    MIHAELA VIOLETA GHICA, LĂCRĂMIOARA POPA, ST. MOISESCU
    Abstract


  9. BIOEQUIVALENCE ESTIMATION BASED ON PEAK AREAS OF UNKNOWN METABOLITES .
    VALENTINA ANUTA, A. ALDEA, OLIMPIA NEAGU, I. MIRCIOIU, DALIA MIRON, F. RADULESCU, MONICA SOARE-RADA, F. ENACHE
    Abstract


  10. CARDIAC GLYCOSIDES - A HISTORICAL REVIEW OF THEIR USE IN BULGARIAN FOLK MEDICINE .
    JENY ANTONOVA
    Abstract


  11. PRELIMINARY IN VITRO STUDIES ON MESENCHYMAL STEM CELLS AND MELANOMA CELLS OF DRY BIRCH TREE BARK EXTRACT .
    CRISTINA A. DEHELEAN, CAMELIA PEEV , CODRUTA ŞOICA, CALIN A. TATU, SIMONA CÎNTĂ-PÎNZARU, ALEXANDRA T. GRUIA
    Abstract


  12. APOPTOTIC CELL DEATH IN RENAL TISSUE OF CYCLOSPORINE A - TREATED RATS .
    DAMASCHIN C., HERTZOG R., IONESCU L., PATRANICHI B., HERTZOG D., NICULINA MITREA
    Abstract


  13. SYNTHESIS OF NEW THIOUREIDES COMPOUNDS WITH POTENTIAL PHARMACOLOGICAL ACTIVITY FROM THIOPHENE-3-CARBOXYLIC ACID .
    CARMELLINA DANIELA BADICEANU, AL. MISSIR
    Abstract


  14. POLYVINYLPYRROLIDONE VA 64 IN THE FORMULATION OF SOME PROTECTIVE FILMS FOR SIMVASTATINE TABLETS .
    EMMA CRETU, VICTORIA HÎRJĂU, DUMITRU LUPULIASA, MIRCEA HÎRJĂU, TEODORA BALACI, CĂTĂLINA LAZĂR
    Abstract


  15. THE ANALYSIS OF THE ACUTE INTOXICATION WITH ALCOHOL, DRUGS AND TOXIC SUBSTANCES IN CHILDREN AND ADOLESCENTS IN CLUJ COUNTY BETWEEN 1990 AND 2004 .
    FLOAREA MOCEAN, DANIELA ZAHARIA, KINGA-JULIA FERENCZ
    Abstract




ABSTRACTS:

1. PHARMACEUTICAL APPLICATIONS OF IONIC ASSOCIATIONS.
NOTE I.

MARINELA FLOREA*, CRINA-MARIA MONCIU, CORINA-CRISTINA ARAMĂ

University of Medicine and Pharmacy"Carol Davila" Bucharest Faculty of Pharmacy, Department of Analytical Chemistry
*corresponding author: florea.marinela@gmail.com


- Abstract -

Ion pair formation, initially investigated by the physical chemistry has found extremely interesting for the chemical analysis (including pharmaceutical analysis), but also for optimizing the drug formulation. Though not exhaustive, the aim of this article was to emphasize the most important applications of the ion pairs in pharmaceutics, based on data published in the last 17 years. Note I presents data on ion-pair formation, specific methods for their analysis with examples from pharmaceutical area and applications of ionic associations in optimizing drug formulation.

- ion pairs
- pharmaceuticals
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2. PATIENT EDUCATION - A NEED FOR THE RATIONAL USE OF ANTIBIOTICS.
CORINA MACAVEI, CODRUTA MAIER, M. BOJITĂ

"Iuliu-Haţieganu" University of Medicine and Pharmacy, Cluj-Napoca, Faculty of Pharmacy, Street L. Pasteur, no 6
*corresponding author: cmacavei@umfcluj.ro


- Abstract -

Antibiotic (AB) resistance is an issue that requires constant effort of healthcare authorities, as well as collaboration between doctors and pharmacists. Previous research identified and analyzed the causes leading to the abusive use of antibiotics; they also included the irrational drug prescription and the pressure that patients put on physicians and pharmacists.

- Antibiotics
- Patient
- Flu
- Cold
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3. NEW AMIDES OF 2-PHENOXYMETHYL-BENZOIC ACIDS AS POTENTIAL ANTIMICROBIAL AGENTS .
DIANA CAMELIA NUTĂ1*, CARMEN LIMBAN1, CAMELIA ELENA STECOZA1, L. MORUSCIAG1, CORINA ILIE2, M.T. CĂPROIU3, G.M. NITULESCU1, CARMELLINA BĂDICEANU1

1Medicinal Chemistry Department, Faculty of Pharmacy, University of Medicine and Pharmacy Carol Davila, Traian Vuia str. no.6, Bucharest
2The National Institute for Chemical Pharmaceutical Research and Development ICCF Bucharest, Calea Vitan 112
3The Organic Chemistry Center of Romanian Academy, "C.D. Nenitescu", Splaiul Independentei no. 202B, Bucharest
*corresponding author: diananuta@yahoo.com


- Abstract -

Concerning the experience in synthesis of N-(2-dialkylaminoethyl)-benzanilides with antimicrobial effect, especially against Staphylococcus aureus strains, we developed a new seria of compounds, some amides of the 2-phenoxymethyl-benzoic acids. The new substances were characterized by their physicochemical properties and by 1H-NMR, 13C-NMR and IR spectral analysis.

- amides of the 2-phenoxymethyl-benzoic acids
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4. DETERMINATION OF PHYSICO-CHEMICAL AND FLOW PROPERTY OF COMMONLY USED DIRECT COMPRESSION BINDER -FILLER POWDERS .
ESAM. A. RAMADAN

University Alfath, Faculty of Pharmacy, Tripoli, Libya
*corresponding author: esamramadan2001@yahoo.de


- Abstract -

This study investigated the basic physico-chemical properties and compact analysis of commonly used commercial direct compression binders/fillers. In general, the starch category exhibited the highest moisture content followed by lactose. Dibasic calcium phosphate (DCP) displayed the highest density, followed by sugar, lactose, starch, and microcrystalline cellulose (MCC). The data also demonstrated that MCC had moderate flow ability, excellent compressibility, and extremely good compact hardness. Starch, lactose, and sugar generally exhibited moderate flow ability, compressibility, and hardness. DCP had excellent flow ability, but poor compressibility and hardness.

- direct compression (DC)
- dibasic calcium phosphate
- microcrystalline cellulose
- tensile strength
- hardness
- friability
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5. SYNTHESIS AND ANTICANCER ACTIVITY IN VITRO OF SOME 2-THIOXO-4-THIAZOLIDONE DERIVATIVES.
OLEXANDRA ROMAN, ROMAN LESYK*

Department of Pharmaceutical, Organic and Bioorganic Chemistry, Danylo Halytsky Lviv National Medical University, 79010 Lviv, Ukraine.
*corresponding author: dr_r_lesyk@org.lviv.net


- Abstract -

Following reaction of 3-methoxy-4-oxybenzoic acid hydrazide and thiocarbonyl-bis-thioglicolic acid, 3-(3-methoxy-4-hydroxybenzoylamino)-2-thioxo-4-thiazolidone (2) was synthesized as starting compound for obtaining of new 5-arylidenederivatives (3-6) in Knoevenagel condensation with aromatic aldehydes. Synthesized compounds displayed antitumor activity on Leukemia, CNS cancer, Melanoma, Ovarian cancer and Breast cancer cell lines. 5-Phenylpropenylidene-3-(3-methoxy-4-hydroxybenzoylamino)-2-thioxo-4-thiazolidone (6) with strong anticancer activity in vitro was identified.

- 2-Thioxo-4-thiazolidones
- Knoevenagel condensation
- Anticancer in vitro screening
- Structure - activity relationship
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6. BIOAVAILABILITY STUDY ON ACETAMINOPHEN TABLETS FROM THE LIBYAN MARKET. IN VITRO/IN VIVO CORRELATION.
ESAM. A. RAMADAN

University Alfath, Faculty of Pharmacy, Tripoli, Libya
*corresponding author: esamramadan2001@yahoo.de


- Abstract -

Three brands of acetaminophen tablets available on the Libyan market namely Panadol®, Paracetamol® and the Tunisian product, Pandol®, were tested in vitro for hardness, friability, disintegration and dissolution. In vivo absorption testing was carried out using human volunteers. The results revealed high friability and very low hardness of the Tunisian Pandol® tablets. The fragility of these tablets was probably the main reason behind the high dissolution rate of acetaminophen from Tunisian Pandol® tablets. In vivo results, saliva and serum levels of acetaminophen, have confirmed this conclusion. Initial absorption was high in the case of Panadol® with Tmax-120min, Cmax=30.8µg/mL, and mean AUC=59.78 µg.h/mL compared to Paracetamol® tablets with Tmax-45 min, Cmax=19.05µg/mL, and mean AUC=66.59 µg.h/mL.However, the calculated Area -under serum conc. time curve (AUC) for the two products have shown a slight increase in the amount of active substance absorbed from Paracetamol® tablets with no significant statistical difference (p>0.05). The results also showed significant levels of salivary acetaminophen (p < 0,001) in the case of Panadol®.

- direct compression (DC)
- dissolution
- bioavailability
- saliva
- serum
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7. EXPERIMENTAL PHARMACOLOGICAL RESEARCHES REGARDING ACUTE TOXICITY AND THE EFFECT ON BASELINE GLYCAEMIA OF SOME NEWLY SYNTHETIZED BETA3 ADRENERGIC RECEPTORS AGONISTS.
SIMONA NEGRES1, CORNEL CHIRITĂ1, CRISTINA ZBÂRCEA1, AURELIA NICOLETA CRISTEA1, ELENA MOROSAN1, DENISA MIHELE1, GABRIELA PUTINA2

1Faculty of Pharmacy, University of Medicine and Pharmacy Carol Davila, Traian Vuia str. no.6, Bucharest
2Romanian National Institute of Chemical-Pharmaceutical Research and Development - Bucharest, Romania


- Abstract -

Adrenergic beta 3 receptors were first characterized in 1989, and after that, their distribution in certain tissues was established: white and brown fat tissue, nervous central system, heart muscle, blood vessels, gastrointestinal smooth muscles, gallbladder, prostate, skeletal muscles. In non-clinical trials it has been demonstrated their major involvement in the glucidic metabolism and, implicitly, in insuline release and also obesity.
Experimental pharmacological trials were performed for six compounds (identified as C1, C2, C3, C4, C5, C6), structurally similar to BRL37344, a selective agonist on beta3 receptors [1]. Acute (single dose) toxicity following oral administration in mice was determined. Effect of investigated compounds on baseline glycaemia was determined in non-diabetic rats following single oral dose.
Experimental results led to establishing the following lethal dose 50% (LD50) in mice: C1 - 210 mg/kg; C2 - 672,72 mg/kg; C3 - 1023,98 mg/kg; C4 - 1586,52 mg/kg..No LD50 was established for C5. For C6 a LD25 was determined (for doses over 100 mg/kg, lethality reached a plateau of 30%).
Experimental results assessing the effect on baseline glycaemia in non-diabetic rat showed a statistically significant decrease of glycaemia compared to control group (treated with distilled water) for the compounds: C2 (50 mg/kg, p.o.) [p=0.01]; C4 (100 mg/kg, p.o.) [p= 0,01]; C5 (100 mg/kg, p.o.) [p=0,04]; C6 (100 mg/kg, p.o.) [p=0,02].

- agonist on beta3 receptors
- acute toxicity
- baseline glycaemia
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8. EVALUATION OF SOME RHEOLOGICAL PARAMETERS FOR SODIUM CARBOXYMETHYLCELLULOSE TOPICAL HYDROGELS WITH INDOMETHACIN.
MIHAELA VIOLETA GHICA*, LĂCRĂMIOARA POPA, ST. MOISESCU

Department of Physical Chemistry, Faculty of Pharmacy, University of Medicine and Pharmacy "Carol Davila", 6 Traian Vuia, Bucharest, 020956, Romania
*corresponding author: mihaelaghica@yahoo.com


- Abstract -

The aim of this paper is the study of some rheological properties for topical hydrogels containing indomethacin and a mixture of gelling polymer (sodium carboxymethylcellulose, NaCMC) and non-gelling polymers (polyethylenglycol 400, PEG 400 and polyethylenglycol 1000, PEG 1000). The rheological measurements have been performed at 230C and 370C. The application of Cross model relating the viscosity and the shear rate data indicated for each gel a non-newtonian pseudoplastic behaviour at both temperatures. The designed hydrogels showed also at both temperatures a thixotropic behaviour quantified through several thixotropic parameters: ascending area, descending area, thixotropic area, thixotropy index.
The rheological properties described in this paper provide reliable informations on hydrogels structure and viscosity, as well as on the hydrogel behaviour at application site, because the drug release from the gel to the skin surface is strongly influenced by the flow parameters of the system.

- Topical hydrogels
- Cross model
- Thixotropic parameters
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9. BIOEQUIVALENCE ESTIMATION BASED ON PEAK AREAS OF UNKNOWN METABOLITES.
VALENTINA ANUTA1,2*, A. ALDEA3, OLIMPIA NEAGU4, I. MIRCIOIU1, DALIA MIRON1,2, F. RADULESCU1,2, MONICA SOARE-RADA1, F. ENACHE5

1 Biopharmacy & Pharmacol Res, 23 Pitar Mos Str., Bucharest, Romania
2UMF Carol Davila, Faculty of Pharmacy, 6 Traian Vuia Str., Bucharest, Romania
3Pfizer Romania S.R.L., Bucharest, Romania
4National Medicine Agency, Bucharest, Romania
5Petru Poni Technical College., Onesti, Romania
*corresponding author: office@bpres.ro


- Abstract -

Te aim of this study was the evaluation of some specific bioanalytical approaches for determination of metabolites pharmacokinetics in bioequivalence studies.
Particularly it is considered the possibility of evaluation of bioequivalence in case of lack of standards for metabolites.
Liquid-liquid extraction of plasma samples followed by reversed-phase mechanism separation and flourescence detection was chosen for the determination of tramadol and its active metabolite O-desmethyl-tramadol in plasma samples. The internal standard was propranolol. HPLC method used a Kromasil 100-5 C18 column, with a gradient elution with a flow rate of 1 mL/min, at 30°C column temperature. 24 healthy volunteers were enrolled into a single-dose (100 mg), two-way, cross-over bioequivalence study. Method 1 considered only metabolite's peak area in pharmacokinetic evaluation of the products. Method 2 used the ratio between the metabolite's peak area and internal standard's peak area in pharmacokinetic evaluation. The third method was the usual method used in evaluation of pharmacokinetics - based on concentrations. The results of the three methods for evaluating pharmacokinetics and bioequivalence were compared.
For both alternative methods the estimations concerning 90% confidence intervals for ratios of pharmacokinetic parameters defining bioequivalence were quite similar to the standard method.
The proposed alternative screening methods, more rapid and simple, can give useful information about bioequivalence, variability in pharmacokinetics associated with formulation and help fenotyping of subjects or identifying outliers.

- pharmacokinetic validation
- metabolites in bioequivalence
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10. CARDIAC GLYCOSIDES - A HISTORICAL REVIEW OF THEIR USE IN BULGARIAN FOLK MEDICINE.
JENY ANTONOVA

Department of Social Pharmacy, Faculty of Pharmacy, 2 Dunav str, Sofia 1000, Bulgaria
*corresponding author: jantonova7@yahoo.com


- Abstract -

The reported research involves a brief historical review of the use of plants containing cardiac glycosides in the Bulgarian folk medicine. Various studies of Bulgarian folk medicine show that it is founded on realistic premises. Mysticism and superstition are relatively rarely resorted to, precedence is given to real treatment with suitable and not so suitable medical plants, minerals and animal products. The research continues the studies carried out by Bulgarian pharmacologists, using Digitalis lanata ambugia s. fuscencens.

- cardiac glycosides
- historical article
- Bulgarian folk medicine
- Digitalis lanata
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11. PRELIMINARY IN VITRO STUDIES ON MESENCHYMAL STEM CELLS AND MELANOMA CELLS OF DRY BIRCH TREE BARK EXTRACT.
CRISTINA A. DEHELEAN1*, CAMELIA PEEV 1, CODRUŢA ŞOICA1, CALIN A. TATU1, SIMONA CÎNTĂ-PÎNZARU2, ALEXANDRA T. GRUIA3

1University of Medicine and Pharmacy Victor Babes Timisoara, P-ta Eftimie Murgu, nr.2, 300041, Romania
2Babes Bolyai University, Faculty of Physics, Molecular Spectroscopy Department, Kogalniceanu 1, RO 400084 Cluj-Napoca, Romania
3County Hospital Timisoara, Romania, Immunology Department
*corresponding author: cadehelean@umft.ro


- Abstract -

The aim of this study was to evidence the therapeutic/toxic activity of a dry outer bark of birch tree extracts (Betula pendula Roth) on mesenchymal stem cells and A2058 (metastatic melanoma). Vibrational AT-IR and FT-Raman spectroscopy has been performed in order to characterise physically and chemically the birch extract. In vitro toxicologic analysis was performed by a standardized colorimetric MTT ([3-(4,5-dimethylthiazol-2-yl)2,5-diphenyltetrazolium bromide]) assay. The results were compared with those for betulin alone, a known antitumor compound and abundant in birch bark. The main conclusion is that birch bark extract has higher biological activity on melanoma in vitro and less toxicity.

- birch bark
- antitumor
- melanoma cells
- mesenchimal stem cells
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12. APOPTOTIC CELL DEATH IN RENAL TISSUE OF CYCLOSPORINE A - TREATED RATS.
DAMASCHIN C.1, HERTZOG R.2, IONESCU L.2, PATRANICHI B.2, HERTZOG D.3, NICULINA MITREA4

1Central Military Hospital, Bucharest
2Army Center for Medical Research, Bucharest
3UMF Craiova, Pharmacology Department
4UMF Carol Davila Bucharest, Faculty of Pharmacy, Biochemistry Department


- Abstract -

Cyclosporine A (CsA) is an immunosupressive agent used in renal transplant recipients. The clinical utility of cyclosporine A is limited by its nephrotoxicity and apoptotic tubular cell death contributes to that. The aim of the study was to check direct toxic effect of CsA on renal tubule epithelia. Identification of apoptotic cell death on renal tissue sections was achieved by fluorescence TUNEL (terminal transferase-mediated dUTP nick end-labeling) assay. The results showed that CsA induced apoptosis in proximal and distal tubule epithelial cells from CsA-treated rat kidney, in a time- and dose-dependent manner. Apoptosis plays a role in pathogenesis of CsA nephrotoxicity.

- Apoptotic cell death
- Cyclosporine A
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13. SYNTHESIS OF NEW THIOUREIDES COMPOUNDS WITH POTENTIAL PHARMACOLOGICAL ACTIVITY FROM THIOPHENE-3-CARBOXYLIC ACID.
CARMELLINA DANIELA BADICEANU*, AL. MISSIR

University of Medicine and Pharmacy "Carol Davila", Faculty of Pharmacy Traian Vuia 6, Sect. 2, Bucharest Departament of Pharmaceutical Chemistry
*corresponding author: bcarmellina@yahoo.com


- Abstract -

The paper represents a continuation of our research in the category of thiophene-3-carboxylic acid derivatives, especially about some new thioureides of this acid with potential pharmacological activity.
The new compounds were obtained using as raw material 3-thenoil-isothiocyanate through condensation with different amines. The isothiocyanate was synthesized by condensation of thiophene-3-carboxylic acid chloride with ammonium thiocyanate, in anhydrous acetone. The mentioned chloride results from the reaction of the thiophene-3-carboxylic acid with thionyl chloride. The obtain compounds, new, unread by the speciality literature, have been characterized by their main physical constants (melting point, solubility) and by spectral analysis 1H-RMN and 13C-RMN. The neccesary reaction conditions have been established in order to obtain compounds with better yields and high purity.
The analysis of the obtained spectral data and the results of the elemental analysis help us to conclusion that the synthesis of the new compounds followed the way that we wanted.

- Athioureea derivatives
- thioureides
- 3-thiophenecarboxylic acid
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14. POLYVINYLPYRROLIDONE VA 64 IN THE FORMULATION OF SOME PROTECTIVE FILMS FOR SIMVASTATINE TABLETS.
EMMA CRETU*, VICTORIA HÎRJĂU, DUMITRU LUPULIASA, MIRCEA HÎRJĂU, TEODORA BALACI, CĂTĂLINA LAZĂR

Faculty of Pharmacy, University of Medicine and Pharmacy Carol Davila, Traian Vuia str. no.6, Bucharest
*correspondence: emmacretu@aim.com


- Abstract -

Currently, the pharmaceutical industry is manufacturing film-coated tablets with simvastatine in various concentrations, using cellulose derivatives as film-forming agents: methylcellulose, ethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methylcellulose. It is a well-known fact that simvastatine is degraded by high temperatures, humidity, light and other oxidizing agents, therefore the processing of this substance as film-coated tablets is preferred.
The present study accentuates the importance of using a superdisintegrating agent in the formulation of the protective film, namely polyvinylpyrrolidoneVA 64. We have selected this polyvinylpyrrolidone type for its good plasticizing properties in coating films, as well as for its binding and superdisintegrating properties. The aim was to improve the stability of the final product and the pharmacotechnical and pharmacokinetical properties, mainly the dissolution rate of the drug. The coated tablets we prepared contained 20 mg of simvastatine. The tablet cores were produced by the classic method of compression after wet granulation, changing the formulation of the protective film, applied by fluid-bed coating.

- polyvinylpyrrolidone VA 64
- simvastatine
- film-coated tablets
- protective film
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15. THE ANALYSIS OF THE ACUTE INTOXICATION WITH ALCOHOL, DRUGS AND TOXIC SUBSTANCES IN CHILDREN AND ADOLESCENTS IN CLUJ COUNTY BETWEEN 1990 AND 2004.
FLOAREA MOCEAN1, DANIELA ZAHARIA2, KINGA-JULIA FERENCZ1

1Department of Public Health and Management, University of Medicine and Pharmacy "Iuliu Haţieganu", 13, Emil Isac Street, 400023, Cluj-Napoca, Romania
2Institute of Forensic Medicine, 3, Clinicilor Street, 400006, Cluj-Napoca, Romania
*corresponding author: e-mail: florymocean@yahoo.com


- Abstract -

The increasing incidence and prevalence of acute intoxication among children and adolescents together with the high incidence of death or the serious consequences of voluntary or accidental ingestion of some toxic substances represent a major socio-pediatric and public health problem. Our descriptive, retrospective, observational epidemiologic study included the cases of acute intoxication in children and adolescents (659 cases = 100%) between 1990-2004 requested by pediatric hospitals from Cluj in order to be analyzed by the forensic toxicology laboratory of the Institute of Forensic Medicine. The largest ratio of acute intoxication was held by the age group 15-18 years: 51.75% and children (0-4 years) with 21.70% from the total cases. The urban environment was prevalent in all cases. Central nervous system depressants were the most frequent cause of acute intoxication 45.75%, followed by alcohol alone or associated with other toxic substances 20.88%, and insecticides 10.86 %. The average starting age for this bad habit has decreased; thus, from the total number of intoxication cases in which alcohol was present, 22.00 % were in the group aged 5-14 years and 77.00% in the group aged 15-18 years. Adolescents, the family, along with the interdisciplinary team (physicians, pharmacists, teachers, psychologists, clergymen) must be involved more actively in order to have a major role in the preventive education concerning consumption of alcohol, drugs and toxic substances, so as to prevent acute intoxication and addiction.

- acute intoxication
- alcohol and drugs
- children and adolescents
- public health
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